Biological Sciences Program

The Biological Sciences (BS) Program is designed for researchers and professionals with interests in the biological processes that underlie aging. Symposia and poster sessions will address the aging process at the molecular, cellular, and organismal level, as well as the specific disease conditions that are related to, or that accompany, the aging process.  Organized by the GSA Biological Sciences Section.

Funding for this conference was made possible, in part by 1R13AG059414-01 from National Institute on Aging. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.

Experience five days of learning and training that include:

2018 Biological Sciences Program

Wednesday, November 14

8 am to 12 pm •  Fee: $0, registration required
Pre-Conference Workshop
Geroscience and the Hallmarks of Aging
Chair: Felipe Sierra
Faculty: Viviana Perez, Marissa Schafer, Meng Wang, Saul Villeda, Johan Auwerx, David Glass, Danica Chen, Ammanuelle Passegue, Rafael de Cabo
Geroscience is an important approach to translate the basic findings in aging biology into interventions that might profit elderly patients.  The aim is to delineate the cellular and molecular mechanisms linking aging with chronic diseases and conditions. The long-term goal is to develop interventions that target aging, the major and common risk factor for most of these diseases and conditions. The major molecular and cellular underpinnings of aging were described in two seminal papers in 2013 and 2014, and these identified a set of 7-9 hallmarks or pillars of aging. In many cases, interventions that modify these pillars result in resistance or delay of chronic diseases and conditions in animal models. This pre-conference will focus on re-visiting some of the progress done in the last 5 years in terms of some of these hallmarks.

2:30 to 4 pm
Decline in Physical Resilience With Age
Chair: Svetlana Ukraintseva

  • Decline in Physical Resilience During Aging: Potential Mechanisms and Role in Health & Longevity, Svetlana Ukraintseva, Anatoliy Yashin, Konstantin Arbeev, Alex Kulminski, Eric Stallard
  • In Search of Biomarkers of Resilence: Measuring Donor-Specific Responses to Stress in Cell-Based Assays, Dora Il'yasova, Alexander Kinev
  • Biomarkers of Resilience in Murine Models, Felipe Sierra, Francesca Macchiarini
  • How do we Recognize Physical Resilence? A Review of Markers and Measures Across Human Studies, Heath E. Whitson, Cathleen Colon-Emeric

4:30 to 6 pm
Insulin/IGF-1 Signaling Pathway in Healthy Aging
Chair: Dudley Lamming

  • mTORC2 in the Regulation of Mammalian Longevity, Dudley Lamming
  • Regulation of Growth by the mTOR Pathway, David Sabatini
  • Regulation of Glucose Storage Extends Lifespan and Promotes Healthspan, Heidi Tissenbaum, Yonghak Seo, Samuel Kingsley, Griffin Walker,Michelle A. Mondoux
  • Insulin/IGF/FOXO Signaling in Stem Cells and Aging, Ashley Webb

Thursday, November 15

8 to 9:30 am
Exercise and Musculoskeletal Determinants of Aging
Chair: LaDora Thompson

  • Maintenance of Proteostasis as a Pillar of Slowed Aging: Lessons from Long-Live Murine Models, Karyn L. Hamilton
  • Preclinical Models of Inactivity and Bedrest to Investigate Muscle Atrophy, LaDora Thompson
  • A Role for Nrf2 Activation in Delayed Aging: Evidence from Bench to Bedside, Benjamin Miller
  • Nutrient Sensing, Physical Activity and the Regulation of Muscle Growth in Older Adults, Blake Rasmussen

10  to 11:30 am
President’s Opening Plenary Session

12 to 1:30 pm
Biological Sciences Presidential Symposium: Free Radicals and Redox Regulation in Aging
Chair: Kelvin Davies

  • Free Radical Theory of Frailty: Molecular mechanisms of frailty resulting from oxidative stress, José Viňa
  • Cellular Senescence: A novel contributor to brain aging and neurodegenerative disease, Julie K. Andersen
  • Reactive oxygen species, Nrf2 signaling, and human aging and diseases, Donna Zhang
  • Compromised Redox Regulation of Adaptive Homeostasis in Aging, Kelvin J. A. Davies

1 to 3 pm (face-to-face time is 2 to 3 pm)
BS Poster Session

1:45 to 3:15 pm
Importance of Mitochondria in Aging
Chair: Changhan David Lee

  • Stress Resistance and the Integrated Mitonuclear Genomes, Changhan David Lee
  • Role of Mitochondria in Aging, Marcia Haigis
  • Mitochondrial-Derived Peptides: Novel Hormones That Regulate Metabolism During Aging, Pinchas Cohen
  • Microbe-Host Mitochondria Interaction in Longevity Regulation, Meng Wang

3:30 to 5 pm
Oxidative Stress & Age-Related Diseases
Chair: Holly Van Remmen

  • SERCA Activation as an Intervention to Reduce Muscle Atrophy and Weakness, Holly Van Remmen, Rizwan Qaisar, Shylesh Bhaskaran, Shylesh Bhaskaran, Kavithalakshmi Sataranatarajan, Pavithra Premukmar, Kendra Huseman
  • The Role of Mitochondrial Energetics in Cardiac and Skeletal Muscle Aging, Peter Rabinovitch, David J. Marcinek
  • Altered Retinal Resistance to Oxidative Stress with Age-Related Macular Degeneration, Deborah Ferrington
  • Hydrogen Sulfide Ameliorates Kidney Changes in Aging and Diabetes, Balakuntalam S. Kasinath

5:30  to 7 pm
The Decline of Proteostasis in Aging
Chair: Ana Maria Cuervo

  • Selective Autophagy: Can we Target it to Extend Health-Span?, Ana Maria Cuervo
  • Autophagy and Aging: Lessons From Long-Lived C. Elegans, Malene Hansen
  • New Insights into the Proteasome Function and Degradation of Misfolded Proteins, Alfred L. Goldberg, Sudarasanareddy Lokireddy, Hyoung-Tae Kim, Chueh-Ling Kuo, Jordan VerPlank
  • The Proteasome and the Biology of Aging, Daniel J. Finlay

Friday, November 16

8 to 9:30 am
Decline of Adaptive Homeostasis & Hormesis in Aging
Chair: Sean Curran

  • Loss of Mitochondrial Amino Acid Catabolism Metabolism With Age Drives Reproductive Senescence, Sean Curran, Chia-An Yen
  • Reduced GH Signaling Enhances the Ability of an Organism to Respond to Stress, Holly Brown-Borg, Sharlene Rakoczy
  • Ancient Mechanisms by Which Metformin Promotes Healthy Aging, Alexander Soukas
  • To Adapt or Not To Adapt: the Consequences of an Age-Dependent Decline in the Adaptive Homeostasis, Laura Corrales-Diaz Pomatto

11:30 am to 1 pm
BS Section Business Meeting and Award Presentation
Fee: $25 (lunch included), separate registration required

1 to 3 pm (face-to-face time is 1:30 to 2:30 pm)
BS Poster Session

1:15  to 2:45 pm
An Update on Anti-Aging Drug Trials
Chair: Nir Barzilai

  • How to Prove that Aging can be Tamed and that Appropriate Regulation be Followed?, Nir Barzilai
  • Metformin to Augment Strength Training Effective Response in Seniors: The MASTERS Trial, Charlotte Peterson, R. Grace Walton, Douglas Long, Bailey Peck, Cory Dungan, Alejandro Villasante Tezanos, Philip A. Kern, S Craig Tuggle, Jenny Martz, John Reams, Marcas M. Bamman, Ameya Kulkarni, Nir Barzilai
  • Targeting Ageing in Asia, Brian Kennedy, Yap Seng Chong
  • TORC1 Inhibition as a Potential Immunotherapy to Reduce Infections in the Elderly, Joan Mannick

3 to 4:30 pm
ESPO/ Biological Sciences Section Symposium: The Crossroads of Aging—Targeting Immunity, Metabolism, and Cellular Stress

5  to 8:00 pm
Irving S. Wright and Vincent Cristofalo “Rising Star” Award Presentation, Lecture, and Reception
These awards are given by American Federation for Aging Research (AFAR) Inc.

Saturday, November 17

8 to 9:30 am
New Models of Aging
Chair: Berenice Benayoun

  • Epigenomics of Aging in Vertebrates, Bérénice Benayoun, Elizabeth A. Pollina, Anne Brunet
  • Maternal Effects on Offspring Aging: Rotifers as a Model System for Aging, Kristen Gribble
  • Understanding and Modeling Aging Using the Naturally Short-Lived African Turquoise Killfish, Anne Brunet
  • The African Killifish: A New Vertebrate Model to Study Aging and Age-Related Diseases, Rochelle Buffenstein

11:30 am to 1 pm
Kent and Kleemeier Award Lectures

1 to 3 pm (face-to-face time is 1:30 to 2:30 pm)
BS Poster Session

1:15 to 2:45 pm
Chair: Julie Andersen

  • Uncovering a Novel Pathway for Neuronal Autophagy: A New Therapeutic Target for Alzheimer's and Parkinson's Disease?, Julie Andersen
  • Targeting Cannabinoid Type 2 Receptors to Modulate Inflammation and Protect Against Asyn-Induced PD-Like Pathologies, Malu Tansey
  • Ketogenic Diet or BHB Improves Epileptiform Spikes, Memory, Survival in Alzheimer's Model, Eric Verdin
  • Pathological Functions of ApoE in Alzheimer's Disease, Yadong Huang, Chengzhong Wang, Ramsey Najm

3 to 4:30 pm
Fondation Ipsen Longevity Prize Award Lecture

5 to 6:30 pm
Reversing Dysfunction in Aging Tissues
Chair: Amy Wagers

  • Cellular and Genetic Approaches to Rescue Stem Cell Function in Aging Organs, Amy Wagers
  • Cellular Senescence, Aging and Cancer, Judith Campisi
  • Using Non-Invasive Sensory Stimuli to Elicit Neuroprotection in Alzheimer's Disease Mouse Models, Li-Hue Tsai
  • Dysregulation of Lymph Node Function Critically Affects Immune Aging, Janko Nikolich-Zugich

Sunday, November 18

8 to 9:30 am
Determination of Biological Age
Chair: Arnold Mitnitski

  • Biological Age: Just a Metaphor for Heterogeneity in the Health of People at the Same Chronological Age or More?, Arnold Mitnitski
  • Frailty and Biological Age in Animal Models, Susan E. Howlett
  • Methylation Landscapes Underlying Human Biological Aging, Morgan Levine, Eileen Crimmins, Steve Horvath, Luigi Ferrucci
  • Examining the Dimensions of Biological Age, S. Michael Jazwinski, Sangkyu Kim

10 to 11:30 am
Environmental Determinants of Aging
Chair: Caleb Finch

  • The Role of Air Pollution in Healthy Aging, Jennifer Ailshire
  • The Neuroinflammation Hypothesis of Urban Air Pollution Effects in the Brain, Michele Block
  • Aging in the Vietnam Era Twin Study of Aging Smokers, Carol Franz, William Kremen
  • Genetic and Epigenetic Contributions to Aging and Disease Among Smokers, Morgan Levine

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