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Biological Sciences Program

The Biological Sciences (BS) Program is designed for researchers and professionals with interests in the biological processes that underlie aging. Symposia and poster sessions will address the aging process at the molecular, cellular, and organismal level, as well as the specific disease conditions that are related to, or that accompany, the aging process.  Organized by the GSA Biological Sciences Section.

Funding for this conference was made possible, in part by 1R13AG059414-01 from National Institute on Aging. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.

Experience five days of learning and training that include:

2018 Biological Sciences Program

Wednesday, November 14

8 am to 12 pm •  Fee: $0, registration required
Pre-Conference Workshop
Geroscience and the Hallmarks of Aging
Chairs: Felipe Sierra, Rafael DeCabo
Faculty: Marissa Schafer, Saul Villeda, Viviana Perez, Johan Auwerx, David Glass, Danica Chen, Meng Wang
Geroscience is an important approach to translate the basic findings in aging biology into interventions that might profit elderly patients.  The aim is to delineate the cellular and molecular mechanisms linking aging with chronic diseases and conditions. The long-term goal is to develop interventions that target aging, the major and common risk factor for most of these diseases and conditions. The major molecular and cellular underpinnings of aging were described in two seminal papers in 2013 and 2014, and these identified a set of 7-9 hallmarks or pillars of aging. In many cases, interventions that modify these pillars result in resistance or delay of chronic diseases and conditions in animal models. This pre-conference will focus on re-visiting some of the progress done in the last 5 years in terms of some of these hallmarks.

2:30 to 4 pm
Decline in Physical Resilience With Age
Chair: Svetlana Ukraintseva

  • Decline in Physical Resilience During Aging: Potential Mechanisms and Role in Health & Longevity, Svetlana Ukraintseva, Anatoliy Yashin, Konstantin Arbeev, Alex Kulminski, Eric Stallard
  • In Search of Biomarkers of Resilence: Measuring Donor-Specific Responses to Stress in Cell-Based Assays, Dora Il'yasova, Alexander Kinev
  • Biomarkers of Resilience in Murine Models, Felipe Sierra, Francesca Macchiarini
  • How do we Recognize Physical Resilence? A Review of Markers and Measures Across Human Studies, Heath E. Whitson, Cathleen Colon-Emeric
  • Cerebrovascular Hemodynamics, Postural Stability And Falls In Older Adults, Laura K. Fitzgibbon-Collins, Ikdip Brar, Mamiko Noguchi, William McIlroy, George Heckman, Richard Hughson

4:30 to 6 pm
Insulin/IGF-1 Signaling Pathway in Healthy Aging
Chair: Dudley Lamming

  • mTORC2 in the Regulation of Mammalian Longevity, Dudley Lamming
  • Regulation of Growth by the mTOR Pathway, David Sabatini
  • Regulation of Glucose Storage Extends Lifespan and Promotes Healthspan, Heidi Tissenbaum, Yonghak Seo, Samuel Kingsley, Griffin Walker,Michelle A. Mondoux
  • Insulin/IGF/FOXO Signaling in Stem Cells and Aging, Ashley Webb
  • Systemic Elevation of 3-Hydroxyanthranilic Acid (3HAA) to Extend Lifespan and Delay Alzheimer’s Pathology, George L. Sutphin

6 to 8 pm
President's Welcome Reception and Exhibit Hall Opening
BS Poster Session (Face-to-Face Time with Presenters 6 to 7 pm)

Thursday, November 15

8 to 9:30 am
Exercise and Musculoskeletal Determinants of Aging
Chair: LaDora Thompson

  • Maintenance of Proteostasis as a Pillar of Slowed Aging: Lessons from Long-Live Murine Models, Karyn L. Hamilton
  • Preclinical Models of Inactivity and Bedrest to Investigate Muscle Atrophy, LaDora Thompson
  • A Role for Nrf2 Activation in Delayed Aging: Evidence from Bench to Bedside, Benjamin Miller
  • Nutrient Sensing, Physical Activity and the Regulation of Muscle Growth in Older Adults, Blake Rasmussen
  • miR-19b Expression in Circulation is Associated With Increased Lean Mass After Resistance Training In Older Adults, Donato A. Rivas, Roger Fielding, Townsend Benard, Lee Margolis

10  to 11:30 am
President’s Opening Plenary Session

12 to 1:30 pm
Biological Sciences Presidential Symposium: Free Radicals and Redox Regulation in Aging
Chair: Kelvin Davies

  • Free Radical Theory of Frailty: Molecular Mechanisms of Frailty Resulting From Oxidative Stress, José Viňa
  • Cellular Senescence: A Novel Contributor to Brain Aging and Neurodegenerative Disease, Julie K. Andersen
  • Reactive Oxygen Species, Nrf2 Signaling, and Human Aging and Diseases, Donna Zhang
  • Compromised Redox Regulation of Adaptive Homeostasis in Aging, Kelvin J. A. Davies

This session is co-presented with the Society for Redox Biology & Medicine and the European Society for Free Radical Research.

1:45 to 3:15 pm
Importance of Mitochondria in Aging
Chair: Changhan David Lee

  • Stress Resistance and the Integrated Mitonuclear Genomes, Changhan David Lee
  • Role of Mitochondria in Aging, Marcia Haigis
  • Mitochondrial-Derived Peptides: Novel Hormones That Regulate Metabolism During Aging, Pinchas Cohen
  • Microbe-Host Mitochondria Interaction in Longevity Regulation, Meng Wang
  • Using Proteomics to Elucidate How Voluntary Exercise Combats Aging Phenotypes in mtDNA Mutator Mice, Jaime M. Ross, Giuseppe Coppotelli, Rui Branca, Janne Lehtiö, David Sinclair, Lars Olson

3:30 to 5 pm
Oxidative Stress & Age-Related Diseases
Chair: Holly Van Remmen

  • SERCA Activation as an Intervention to Reduce Muscle Atrophy and Weakness, Holly Van Remmen, Rizwan Qaisar, Shylesh Bhaskaran, Shylesh Bhaskaran, Kavithalakshmi Sataranatarajan, Pavithra Premukmar, Kendra Huseman
  • The Role of Mitochondrial Energetics in Cardiac and Skeletal Muscle Aging, Peter Rabinovitch, David J. Marcinek
  • Altered Retinal Resistance to Oxidative Stress with Age-Related Macular Degeneration, Deborah Ferrington
  • Hydrogen Sulfide Ameliorates Kidney Changes in Aging and Diabetes, Balakuntalam S. Kasinath
  • Pomegranate Juice and Extract Provide Photoprotection against UV-induced Erythema and Changes the Skin Microbiome, Zhaoping Li, Susanne Henning, Jieping Yang, David Heber

5:30  to 7 pm
The Decline of Proteostasis in Aging
Chair: Ana Maria Cuervo

  • Selective Autophagy: Can we Target it to Extend Health-Span?, Ana Maria Cuervo
  • Autophagy and Aging: Lessons From Long-Lived C. Elegans, Malene Hansen
  • New Insights into the Proteasome Function and Degradation of Misfolded Proteins, Alfred L. Goldberg, Sudarasanareddy Lokireddy, Hyoung-Tae Kim, Chueh-Ling Kuo, Jordan VerPlank
  • The Proteasome and the Biology of Aging, Daniel J. Finlay
  • CPNE2: A New Regulator of Lysosomal-Mitochondrial Function Involved in Aging and Disease, Giuseppe Coppotelli, Jaime Ross, Alvin Ling, Kyung Kim, David Sinclair

Friday, November 16

8 to 9:30 am
Decline of Adaptive Homeostasis and Hormesis in Aging
Chair: Sean Curran

  • Loss of Mitochondrial Amino Acid Catabolism Metabolism With Age Drives Reproductive Senescence, Sean Curran, Chia-An Yen
  • Reduced GH Signaling Enhances the Ability of an Organism to Respond to Stress, Holly Brown-Borg, Sharlene Rakoczy
  • Ancient Mechanisms by Which Metformin Promotes Healthy Aging, Alexander Soukas
  • To Adapt or Not To Adapt: the Consequences of an Age-Dependent Decline in the Adaptive Homeostasis, Laura Corrales-Diaz Pomatto
  • Tis11 and Cth1 Deficiency Leads to Metabolic Reprograming and Extends Replicative Lifespan in Yeast, Carine Beaupere, Brian Wasko, Matt Kaeberlein, Vyacheslav Labunskyy

11:30 am to 1 pm
BS Section Business Meeting and Award Presentation
Fee: $25 (lunch included), separate registration required

1:15  to 2:45 pm
An Update on Anti-Aging Drug Trials
Chair: Nir Barzilai

  • How to Prove that Aging can be Tamed and that Appropriate Regulation be Followed?, Nir Barzilai
  • Metformin to Augment Strength Training Effective Response in Seniors: The MASTERS Trial, Charlotte Peterson, R. Grace Walton, Douglas Long, Bailey Peck, Cory Dungan, Alejandro Villasante Tezanos, Philip A. Kern, S Craig Tuggle, Jenny Martz, John Reams, Marcas M. Bamman, Ameya Kulkarni, Nir Barzilai
  • Targeting Ageing in Asia, Brian Kennedy, Yap Seng Chong
  • TORC1 Inhibition as a Potential Immunotherapy to Reduce Infections in the Elderly, Joan Mannick
  • Zoledronate Extends Lifespan and Healthspan in Vivo, Ilaria Bellantuono, Zhengqi Chen, Cathy Slack, Julia Cordero, Martin Zeidler

3 to 4:30 pm
ESPO/ Biological Sciences Section Symposium: The Crossroads of Aging—Targeting Immunity, Metabolism, and Cellular Stress
Chair:
Kelvin J. A. Davies

  • Aging Impairs Aortic Mitochondrial Function and Enhances Inflammation and Plaque Necrosis in Atherosclerotic Mice, Daniel Tyrrell
  • Heterochronic Parabiosis: Old Blood Attenuates Mitochondrial Bioenergetics of Young Mice, Jenny L. Gonzalez-Armenta, Gargi Mahapatra, K. Allison Amick, Ning Li, Baisong Lu, Anthony Molina
  • Novel and Direct Myofilament-Mediated Action of Metformin In the Aging Right Heart, Danielle Bruns, Elizabeth Kovacs, Mark Jeong, Peter Buttrick, Lori Walker
  • Age-Associated Changes in Mouse Hepatocyte Polarization, Sun Woo Sophie Kang, Dong Fu, David Le Couteur, Victoria Cogger

5  to 8:00 pm
Irving S. Wright and Vincent Cristofalo “Rising Star” Award Presentation, Lecture, and Reception
These awards are given by American Federation for Aging Research (AFAR) Inc.

Saturday, November 17

8 to 9:30 am
New Models of Aging
Chair: Berenice Benayoun

  • Epigenomics of Aging in Vertebrates, Bérénice Benayoun, Elizabeth A. Pollina, Anne Brunet
  • Maternal Effects on Offspring Aging: Rotifers as a Model System for Aging, Kristen Gribble
  • Understanding and Modeling Aging Using the Naturally Short-Lived African Turquoise Killfish, Anne Brunet
  • Disrupting the Epigenome in Novel NICE Mice to Study Age-Related Cognitive Decline, Jaime M. Ross, Giuseppe Coppotelli, João Amorim, Ebba Hillstedt, Emily Potts, David Sinclair
  • Very Long-Chain Ceramides Are Increased in Serum Exosomes With Aging in Both Human Subjects and Non-Human Primates, Priyanka Krishnan, Andrew Khayrullin, Luis Martinez, Bharati Mendhe, Sadanand Fulzele, Yutao Liu

11:30 am to 1 pm
Kent and Kleemeier Award Lectures

1:15 to 2:45 pm
Neurodegeneration
Chair: Julie Andersen

  • Uncovering a Novel Pathway for Neuronal Autophagy: A New Therapeutic Target for Alzheimer's and Parkinson's Disease?, Julie Andersen
  • Targeting Cannabinoid Type 2 Receptors to Modulate Inflammation and Protect Against Asyn-Induced PD-Like Pathologies, Malu Tansey
  • Ketogenic Diet or BHB Improves Epileptiform Spikes, Memory, Survival in Alzheimer's Model, Eric Verdin
  • Pathological Functions of ApoE in Alzheimer's Disease, Yadong Huang, Chengzhong Wang, Ramsey Najm
  • NAD+ Depletion as a Cause of Inflammaging, Michael B. Schultz, Thomas Bochaton, Michael Bonkowski, Jun Li, Doyle Lokitiyakul, Alexander Colville

3 to 4:30 pm
Fondation Ipsen Longevity Prize Award Lecture

5 to 6:30 pm
Reversing Dysfunction in Aging Tissues
Chair: Amy Wagers

  • Cellular and Genetic Approaches to Rescue Stem Cell Function in Aging Organs, Amy Wagers
  • Cellular Senescence, Aging and Cancer, Judith Campisi
  • Using Non-Invasive Sensory Stimuli to Elicit Neuroprotection in Alzheimer's Disease Mouse Models, Li-Hue Tsai
  • Dysregulation of Lymph Node Function Critically Affects Immune Aging, Janko Nikolich-Zugich
  • Impairment of an Endothelial NAD+-H2S Signaling Network Is a Reversible Cause of Vascular Aging, Michael S. Bonkowski, Abhirup Das, Michael B. Schultz, Yuancheng Lu, Jay Mitchell, Lindsey Wu

Sunday, November 18

8 to 9:30 am
Determination of Biological Age
Chair: Arnold Mitnitski

  • Biological Age: Just a Metaphor for Heterogeneity in the Health of People at the Same Chronological Age or More?, Arnold Mitnitski
  • Frailty and Biological Age in Animal Models, Susan E. Howlett
  • Methylation Landscapes Underlying Human Biological Aging, Morgan Levine, Eileen Crimmins, Steve Horvath, Luigi Ferrucci
  • Examining the Dimensions of Biological Age, S. Michael Jazwinski, Sangkyu Kim
  • Measuring Biological Age as a Task of Individualization: A Framework for Predictor Selection and Model Validation, Johannes Hertel, Stefan Frenzel, Johanna König, Katharina Wittfeld, Georg Füllen, Maik Pietzner

10 to 11:30 am
Environmental Determinants of Aging
Chair: Caleb Finch

  • The Role of Air Pollution in Healthy Aging, Jennifer Ailshire
  • The Neuroinflammation Hypothesis of Urban Air Pollution Effects in the Brain, Michele Block
  • Aging in the Vietnam Era Twin Study of Aging Smokers, Carol Franz, William Kremen
  • Genetic and Epigenetic Contributions to Aging and Disease Among Smokers, Morgan Levine
  • Cigarettes and Air Pollution Show Convergent Interactions With ApoE-sex in Humans and MiceCigarettes and Air Pollution Show Convergent Interactions With ApoE-sex in Humans and Mice, Amin Haghani, Mafalda Cacciottolo, Kevin Doty, Constantinos Sioutas, Terrence Town, Todd Morgan

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