Biological Sciences Program

The Biological Sciences (BS) Program is designed for researchers and professionals with interests in the biological processes that underlie aging. Symposia and poster sessions will address the aging process at the molecular, cellular, and organismal level, as well as the specific disease conditions that are related to, or that accompany, the aging process.  Organized by the GSA Biological Sciences Section.

Funding for this conference was made possible, in part by 1R13AG059414-01 from National Institute on Aging. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.

Experience five days of learning and training that include:

  • Symposium and Poster Sessions
  • Geroscience Pre-Conference NIA Workshop
  • Biological Sciences Section Luncheon
  • Presentation of the Wright and Cristofalo Award and the Fondation Ipsen Longevity Prize Award
  • Multiple opportunities to build your professional contacts

The Biological Sciences Section Program:

Presidential Symposium: Free Radicals and Redox Regulation in Aging

  • Free Radical Theory of Frailty: Molecular mechanisms of frailty resulting from oxidative stress, José Viňa
  • Cellular Senescence: A novel contributor to brain aging and neurodegenerative disease, Julie Andersen
  • Reactive oxygen species, Nrf2 signaling, and human aging and diseases, Donna Zhang
  • Compromised Redox Regulation of Adaptive Homeostasis in Aging, Kelvin J. A. Davies

Exercise and Musculoskeletal Determinants of Aging

  • Preclinical Models of Inactivity and Bedrest to Investigate Muscle Atrophy, LaDora Thompson
  • Nutrient Sensing, Physical Activity and the Regulation Skeletal Muscle Growth in Older Adults, Blake Rasmussen
  • Maintenance of Proteostasis as a Pillar of Slowed Aging: Lessons from Long-Live Murine Models, Karyn L. Hamilton
  • A Role for Nrf2 Activation in Delayed Aging: Evidence from Bench to Bedside, Ben Miller

Importance of Mitochondria in Aging

  • Cross-Genomic Basis of Mitonuclear Communication, Changhan David Lee
  • The Function of Mitochondrial Sirtuns in metabolism and Aging, Marcia Haigis
  • Precision Mitochondrial Medicine for Diseases of Aging, Pinchas Cohen
  • Microbe-Host Mitochondria Interaction in Longevity Regulation, Meng Wang 

Oxidative Stress & Age-Related Diseases

  • Are Muscle Mitochondrial Reactive Oxygen Species the Cause for Sarcopenia?, Holly Van Remmen
  • Role of Mitochondria and Reactive Oxygen Species, Peter Rabinovitch
  • Altered Retinal Resistance to Oxidative Stress with Age-Related Macular Degeneration, Deborah Ferrington
  • H2S Modulation of NADPH Oxidase and Oxidative Stress in Kidney Dysfunction During Aging and Diabetes, Balakuntalam S. Kasinath


  • Selective Autophagy: Can we Target it to Extend Health-Span?, Ana Maria Cuervo
  • New Insights into the Proteasome Function and Degradation of Misfolded Proteins, Alfred L. Goldberg
  • The Role of the Ubiquitin-Proteasome Pathway in the Biology of Aging, David J. Finley
  • Autophagy and Aging: Lessons From Long-Lived C. Elegans, Malene Hansen

Decline of Adaptive Homeostasis & Hormesis in Aging

  • Loss of Mitochondrial Amino Acid Catabolism Metabolism With Age Drives Reproductive Senescence, Sean Curran
  • Maintenance of a Young Epigenomic Profile Extends Health and Longevity, Holly Brown-Borg
  • Nuclear Leakiness, Aging, and mTPR Signaling: Lessons from Metformin, Alex Soukas
  • Defective Nrf2 Proteasome, and Lon Inducibility as Evidence for Loss of Adaptive Homeostasis in Aging, Laura Pomatto

Anti-Aging Drug Trials

  • How to Prove that Aging can be Tamed and that Appropriate Regulation be Followed?, Nir Barzilai
  • Life Style (Exercise) and Drug (Metfoormin) for Targeting Aging in Elderly, Charlotte Peterson
  • Acarbose for Targeting Aging in the Orient, Yap Seng Chong, Brian Kennedy
  • Development of Safe and Efficacious Rapalogues, Joan Mannick

New Models of Aging

  • Epigenomics of Aging Reactive Oxygen Species Vertebrates, Bérénice Benayoun
  • Intraspecific Variability and Maternal Effects: Rotifers as a Model System for Aging, Kristen Gribble
  • Understanding and Modeling Aging Using the Naturally Short-Lived African Turquoise Killfish, Anne Brunet
  • The Bare Essentials of Aging: Lessons Learnt from the Long Lived Naked Mole-Rate, Rochelle Buffenstein


  • Discovery and Chracterization of a Novel Signaling Pathway Involved in the Regulation of Neuronal Autophagy: Investigation as a Novel Therapeutic Target for Parkinson's and Alzheimer's Diseases, Julie Andersen
  • Neuroinflammatory and Immune System Responses in Age-Related Neurodegenerative Diseases, Malu Tansey
  • Use of Ketogenic Diet as a Therapeutic for Alzheimer's Disease, Eric Verdin
  • Pathological Functions of ApoE in Alzheimer's Disease, Yadong Huang

Reversing Dysfunction in Aging Tissues

  • Cellular and Genetic Approaches to Rescue Stem Cell Function in Aging Organs, Amy Wagers
  • Impact pf Age-Related Fibrosis on Immune Responses in Secondary Lymphoid Organs, Janko Nikolich-Zugich
  • Cellular Senescence, Aging and Cancer, Judith Campiso
  • Using Non-Invasive Sensory Stimulation to Rejuvinate Nervous System Structure and Function, Li-Hue Tsai

Environmental Determinants of Aging

  • Chair: Caleb Finch
  • The Role of Air Pollution in Healthy Aging, Jennifer Ailshire
  • The Neuro Inflammation Hypothesis of Urban Air Pollution Effects on the Brain, Michele Block
  • Aging in the Veteran Twin Study Smokers, Carol Franz
  • Longevity Genes in Cigarette Survivors, Morgan Levine, George Martin, Kaare Christensen

Determination of Biological Age

  • Biological Age: just a Metaphor for Heterogeneity in the Health of People at the Same Chronological Age or More?, Arnold Mitnitski
  • Frailty and Biological Age in Animal Models, Susan E. Howlett
  • A Novel DNA Methylation Estimate of Biological Age, Eileen Crimmins
  • Examining the Dimensions of Biological Age, S. Michael Jazwinski

Decline in Physical Resilience With Age

  • Decline in Physical Resilience During Aging: Potential Mechanisms and Role in Health & Longevity, Svetlana Ukraintseva
  • In Search of Biomarkers of Resilence: Measuring Donor-Specific Responses to Stress in Cell-Based Assays, Dora Il'yasova
  • Biomarkers of Physical Resilience in Murine Models, Felipe Sierra
  • How do we recognize Physical Resilence? A Review of Markers and Measures Across Human Studies, Heath E. Whitson

Insulin/IGF Signaling Pathway in Healthy Aging

  • mTORC2 in the Regulation of Mammalian Longevity, Dudley Lamming
  • Regulation of Growth by the mTOR Pathway, David Sabatini
  • Regulation of Glucose Storage Extends Lifespan and Promotes Healthspan, Heidi Tissenbaum
  • Insulin/IGF/FOXO Signaling in Stem Cells and Aging, Ashley Webb


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