A new supplement issue of The Gerontological Society of America’s journal The Gerontologist marks 20 years of public health leadership on dementia through the U.S. Centers for Disease Control and Prevention’s Healthy Brain Initiative (HBI) and highlights unprecedented progress in establishing dementia as a public health priority nationwide. Accelerated through implementation of the federal government’s Building Our Largest Dementia Infrastructure (BOLD) Act, the supplement documents how brain health, dementia risk reduction, early detection, and caregiving are now core components of public health practice.